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Autophagy protects against ischemia/reperfusion-induced lung injury through alleviating blood-air barrier damage.

Identifieur interne : 000E99 ( Main/Exploration ); précédent : 000E98; suivant : 000F00

Autophagy protects against ischemia/reperfusion-induced lung injury through alleviating blood-air barrier damage.

Auteurs : Dan Zhang [République populaire de Chine] ; Chichi Li [République populaire de Chine] ; Jian Zhou [République populaire de Chine] ; Yuanlin Song [République populaire de Chine] ; Xiaocong Fang [République populaire de Chine] ; Jiaxian Ou [République populaire de Chine] ; Jing Li [République populaire de Chine] ; Chunxue Bai [République populaire de Chine]

Source :

RBID : pubmed:25934479

Descripteurs français

English descriptors

Abstract

Understanding the role and underlying regulation mechanism of autophagy in ischemia/reperfusion (I/R)-induced lung injury may provide potentially new pharmacologic targets for treatment of acute lung injury. The aim of this study was to adjust autophagy with pharmacologic agents to determine its functional significance in I/R-induced lung injury.

DOI: 10.1016/j.healun.2014.12.008
PubMed: 25934479


Affiliations:


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Le document en format XML

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<term>Cell Survival</term>
<term>Cells, Cultured</term>
<term>Endothelium, Vascular (metabolism)</term>
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<div type="abstract" xml:lang="en">Understanding the role and underlying regulation mechanism of autophagy in ischemia/reperfusion (I/R)-induced lung injury may provide potentially new pharmacologic targets for treatment of acute lung injury. The aim of this study was to adjust autophagy with pharmacologic agents to determine its functional significance in I/R-induced lung injury.</div>
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